Well they stay you should always start wit hthe small things...
I thought I'd start with a topic I find fascinating, that's touched on it 2 of my favourite future sci-fi cyberpunk stories, GiTS and Deus Ex, as they both approach the problem of the future in an information age, with the advance of technology.
Nanotechnology, the technology of stuff on a mind-blowingly small scale, is something that is not addressed directly for the most part in GiTS, but is often mentioned in connection with prosthetics and cyberbrain technology. There is of course also that old chestnut, the Japanese Miracle too.
In Deus Ex it forms the foundation of the storyline. In the DeE universe mankind has surpassed prosthetics (which leave users with a maimed and disfigured half-human/half-machine look) and developed bio-augmentation by way of using nanotechnology. The main protagonists of the story, the Dentons, are nano-augmented human beings, they look relatively normal, except for a few suspicious extra blue veins, but they hold within them the powers of a superhuman. The sinister side of all this, however, is shown at the beginning of Deus Ex 2: Invisible War, when a whole city is all but wiped out by a nanite bomb, a self-replicating terrorist device that disintegrates everything in it's path.
These are two contrasting views on the same idea. What are your views on nanotechnology? Do you see it changing humankind for the better, or are you afraid of the grey goo?
